Well an effective thing to do is to download a linux distro install it on a usb stick and use this gui on the stick. Monero: Downloads
Soon the ledger will be implementing Monero that will defiantly change a lot of things.
I actually just wrote about this: Securely storing a large amount of Monero (XMR) Since officialy the ledger doesn't support XMR I went with a paper wallet, but this is only good for keeping, not for spending...